Antidiabetic and Antioxidative Activity of Chamomile (Matricaria chamomilla L.) Powder on Diabetic Rats

Samah A. Elsemelawy

Abstract


This work is aimed to investigate the effect of chamomile flower and roots on diabetic rats and determine the content of polyphenolic compounds and flavonoid of chamomile. Twenty four adult male albino rats of Sprague Dawley strain, weighting 150 ± 5g were used in this study, the rats were divided into two main groups. Group 1 (6 rats) fed on basal diet as a control (-ve) group. Group 2 was (18 rats) injected with aqueous solution of streptozotocin (55 mg/kg body weight) to induce diabetes by intravenous injection and fed on basal diet as a control (+ve) group. Groups 3 and 4 were administrated 10% and 20% chamomile for 28 days. The results obtained that, the main componants of polyphenolic compounds and flavonoid of chamomile (luteolin O-acylhexoside, querctin, ellagic acid, catechol and chlorogenic acid), respectively. Injected rats with streptozotocin induced significant decrease in feed intake, body weight gain%, HDL-C, acetylcholine esterase, catalase activity and glutathione activity and induced significant increase in (serum brain and glucose), total lipids, cholesterol, triglycerides, LDL-C, VLDL-C and lipid peroxidation, as compared to healthy rats group (non-injected rats). Diabetic rats treated with the levels of 10% and 20% chamomile show significant increasing at the mean value of feed intake, HDL-C, acetylcholine esterase, catalase activity and glutathione activity, on the other hand these treatments induced significant decrease in the other tested parameters, as compared to the (+ve) control. Chamomile improved the nutritional and biochemical status of diabetic rats, especially level at 20% chamomile.

Key words: chamomile, polyphenolic compounds, flavonoides, hyperglycaemia.

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